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Benefits Of Each Ingredient
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Vitamin B6 pyridoxal 5'-phosphate (PLP)
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● Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
● Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
● Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
● May support blood sugar regulation in women with gestational diabetes (40).
● Cofactor for enzymes involved in DNA metabolism (40).
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● Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
● Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
● Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
● Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
● Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn's disease (10, 11).
● Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12).
● Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9).
● Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9).
● Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).
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● Optimizes energy, cognitive function, and mental alertness. (24).
● Supplementation with caffeine has been shown to acutely enhance exercise performance (24).
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● Supports cardiovascular health and exercise performance by increasing production of l-arginine (34).
● Increases nitric oxide production, improves exercise performance, and increases blood flow to exercising skeletal muscle (35).
● Supports strength increases, exercise endurance, and recovery (34,35).
● May reduce blood pressure by increasing vascular function (34).
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Vitamin B-12 (Methylcobalamin)
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● Metabolically active, methylated form of Vitamin B12 needed for proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53).
● Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).
● May prevent vitamin b-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53).
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● Optimizes exercise performance, muscle mass, strength, thermoregulation, recovery, and intramuscular stores of phosphocreatine (PCr) (47).
● Vital for the energy reaction of every cell in the human body as a spatial energy shuttle and energy sensor (47,50).
● Vital in bioenergetics (metabolic activity) of the brain (50).
● Fuels CD8 and CD4 T- cell mediated immunity (immune cells) in cancer tissue (48,49).
● Supports cognition and focus via replenishment of cerebral storage of creatine (creatine in the brain) (50).
● Supports cognitive health in brain creatine deficiency associated neurodegenerative diseases (50).
● Supports cognitive health by enhancing the facilitation of synaptic glutamate and neurotransmitter uptake (50).
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● Supports conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93).
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● Supports aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94).
● Supports cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95).
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● Supports energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96).
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● Supports immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98).
● Supports immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98).
● Supports fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98).
● Supports accelerate bone healing after a fracture, increase type I collagen synthesis, and reduce oxidative stress (inflammation) (98).
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● Supports increased muscle protein synthesis, decreased adipose tissue mass (fat loss), increased creatine synthesis, reduced fatigue from exercise, and improves nitric oxide production (99, 100).
● Supports skeletal muscle hypertrophy by aiding as an anabolic intramuscular Osmolyte (drawing water to muscle cells) (99,100).
● Increases skeletal muscle hypertrophy via increased methionine production and ultimately increased creatine reservoir (99,100).
● Reduces adipose tissue by increasing mitochondrial fatty acid oxidation (fat burning) via increased l-carnitine transport (a molecule that transports to be burned) (99,100).
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● Supports increased mood and hippocampal volume (memory) (101).
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● Supports relaxation, positive mood, increased memory, reduced anxiety, blood sugar regulation, and increased growth hormone production (102).
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● Improves exercise performance, increases nutrient delivery to exercising muscle, and reduces lactate-associatedneurological exercise fatigue (15).
● Reduces carnosine (muscle acidity) levels and acts as an intramuscular ph buffer (15).
● Reduces lactate “burn” associated fatigue during extreme exercise (15).
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